Amplex: Bone Graft Materials | Bone Graft Materials | Mechanism of Action
Amplex™: Mechanism of Action
Amplex is a bone graft alternative that combines our patented B2A® peptide with bioresorbable ceramic bone graft substitute (BGS) to promote bone formation and fusion.
B2A Peptide: B2A is the peptide designed on the cell receptor pathway of bone morphogenic protein 2 (BMP2). BMP2 is a protein found naturally in the body that plays a role in the normal repair of damaged bones. A recombinant BMP2 has been developed by others and has been proven in multiple clinical studies to be a powerful promoter of bone formation. B2A has been designed to work in concert with natural BMP2 to amplify and enhance bone growth during the body’s normal healing process and capitalize on the kinetics, or timing, of the body’s natural BMP2 cascade.
Amplex BGS: The BGS used in Amplex is a bi-phasic ceramic material that closely mimics the properties of native bone. Comprised of both hydroxyapatite (HA) and beta Tri-Calcium-Phosphate (bTCP) this material provides the building blocks for bone cells to begin their repair process. This BGS is designed to be resorbed by the body over time as the bone cells begin laying down mature bone in its place. Ultimately, these synthetic materials are fully replaced by mature, stable bone.
Phase 1 - Implantation
A mixture of Amplex and local bone are placed into the disc space; the Amplex / bone mixture is also packed into a PEEK interbody cage and implanted into the disk space. Click here to view larger image.
Phase 2 - Amplified Healing
Based on in vivo and in vitro data1
B2A is designed to work at the cellular level to improve the body's normal healing response by amplifying the bone repair process. Click here to view larger image.
Phase 3 - Remodeling
Over time, the ceramic scaffold is resorbed by the body as it is replaced by new bone in the disc space. Note presence of bridging bone from endplate to endplate. Click here to view larger image.
Related Terms
Bone morphogenetic proteins (BMPs) Type of growth factor which induces the formation of bone and cartilage.
Growth factor: Naturally-occurring signaling agent capable of stimulating cellular growth, proliferation, and differentiation.
Osteoblasts: Cells that are responsible for bone formation.
Osteoinduction: Acceleration of new bone formation by chemical means.
Peptide: Molecule composed of two or more amino acids; including cellular signaling agents such as growth factors.
Find out more. Visit the North American Spine Society website for more information on bone graft alternatives and bone morphogenetic proteins.
- Data on file with BioSET, Inc.